In the co-main event, Alexa Grasso upset the odds to dethrone Valentina Shevchenko and claim the flyweight title.
In beating Shevchenko, 29-year-old Grasso became Mexico's first female UFC champion.
An ill-judged spinning back-kick from Shevchenko in the fourth round allowed Grasso to take her back and submit the defending champion with a rear-naked choke.
Emotion poured out of Grasso once Shevchenko tapped, after seven years in the UFC working to become a champion.
"Please pinch me because I feel like I'm dreaming," Grasso said.
"It was training, I'm training every single day for that thing because I know she does those spinning things.
"I trained that because I know she hits hard, she's a great athlete."
Shevchenko, 34, had not lost since 2017 and that was to two-weight champion Amanda Nunes at bantamweight.
The Kyrgyzstan-born fighter is considered the UFC's best ever flyweight after claiming the vacant title in 2018 and successfully defending it seven times since then.
Grasso was unfancied coming into the contest but began strongly, utilising her striking in the early minutes and rocking Shevchenko on a few occasions.
Shevchenko went to her wrestling and takedowns and quickly took over, but Grasso remained dangerous on her feet and bided her time before a golden opportunity presented itself.
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